Inducibility of human cytochromes P-450 primarily involved in the activation of chemical carcinogens
β Scribed by Fred F. Kadlubar; F.Peter Guengerich
- Book ID
- 116079299
- Publisher
- Elsevier Science
- Year
- 1992
- Tongue
- English
- Weight
- 258 KB
- Volume
- 25
- Category
- Article
- ISSN
- 0045-6535
No coin nor oath required. For personal study only.
π SIMILAR VOLUMES
Cytochrome P450 is known to cause carcinogen activation and correspondingly increased cancer risk in animal models. In order to determine whether P450 in the colon may be involved in cancer development in the human, the human colon cell line LS174T was examined for the presence of various cytochrome
Different estrogens vary in their carcinogenic potential despite having similar hormonal potencies; however, mechanisms of estrogen-induced carcinogenesis remain to be fully elucidated. It has been hypothesized that generation of reactive estrogenquinones and oxidative stress, both of which result f