Induced pluripotent stem cells in hematology: current and future applications

✍ Scribed by Focosi, D; Amabile, G; Di Ruscio, A; Quaranta, P; Tenen, D G; Pistello, M

• Book ID: 121817179
• Publisher: Nature Publishing Group
• Year: 2014
• Tongue: English
• Weight: 796 KB
• Volume: 4
• Category: Article
• ISSN: 2044-5385
• DOI: 10.1038/bcj.2014.30

✦ Synopsis

Reprogramming somatic cells into induced pluripotent stem (iPS) cells is nowadays approaching effectiveness and clinical grade. Potential uses of this technology include predictive toxicology, drug screening, pathogenetic studies and transplantation. Here, we review the basis of current iPS cell technology and potential applications in hematology, ranging from disease modeling of congenital and acquired hemopathies to hematopoietic stem and other blood cell transplantation.