Induced neuronal expression of class I major histocompatibility complex mRNA in acute and chronic inflammation models
β Scribed by Jane A Foster; Ning Quan; Edra L Stern; Krister Kristensson; Miles Herkenham
- Book ID
- 114137730
- Publisher
- Elsevier Science
- Year
- 2002
- Tongue
- English
- Weight
- 555 KB
- Volume
- 131
- Category
- Article
- ISSN
- 0165-5728
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Mechanisms of major histocompatibility complex (MHC) class I gene regulation in cells of the CNS have been studied in vitro. Astrocytes in primary cultures, but neither oligodendrocytes nor neurons, constitutively expressed cell surface MHC class I molecules. Interferon-gamma (IFN-.I) treatment led
The expression of the major histocompatibility complex Class I antigens (Class I) was investigated in the nervous system of twitcher (C57BL/6J-twi), a murine model of Krabbe disease in humans. Class I mRNA expression was low in wild type and in twitcher mice prior to the onset of demyelination. Howe