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Indoor coal combustion emissions, GSTM1 and GSTT1 genotypes, and lung cancer risk: a case-control study in Xuan Wei, China


Book ID
104275988
Publisher
Elsevier Science
Year
2002
Weight
179 KB
Volume
43
Category
Article
ISSN
0140-6701

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✦ Synopsis


15 Environment (pollution, health protection, safety) This study was focused at estimating the human health risk of the general and working population living in the region polluted by arsenic for more than 40 years, from combustion of coal with high arsenic content in the power plant. The exposure to arsenic from inhalation was under investigation. A study period of 40 years was chosen. The study period was defined taking into account, besides the availability of data, the temporal patterns of the technology processes and the trends over time of environmental concentrations.

The results from the arsenic risk assessment study were used for the evaluation of the health risk for different population groups in the polluted areas and for different professions of workers exposed to As in a power plant. The results are applicable for the evaluation of risk in real conditions, for health surveillance and for remedial changes and a potential suggestion on technology improvement.


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## Abstract Genetic backgrounds may modify the association of environmental tobacco smoke (ETS) with lung cancer risk. Polymorphisms of both the activating and detoxifying enzymes, cytochrome P4501A1 (CYP1A1) and glutathione‐S‐transferase M1 (GSTM1), may be important as genetic factors. We conducte