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Indole-2-carboxamides as Allosteric Modulators of the Cannabinoid CB 1 Receptor

✍ Scribed by Piscitelli, Francesco; Ligresti, Alessia; La Regina, Giuseppe; Coluccia, Antonio; Morera, Ludovica; Allarà, Marco; Novellino, Ettore; Di Marzo, Vincenzo; Silvestri, Romano


Book ID
111691579
Publisher
American Chemical Society
Year
2012
Tongue
English
Weight
394 KB
Volume
55
Category
Article
ISSN
0022-2623

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## Abstract The cannabinoid CB~1~ receptor is a class A G protein‐coupled receptor (GPCR) that is the most widely expressed GPCR in the brain. Many GPCRs contain allosteric binding sites for endogenous and/or synthetic ligands, which are topographically distinct from the agonist‐binding site that i