Individuals with selective IgA deficiency resolve rotavirus disease and develop higher antibody titers (IgG, IgG1) than IgA competent individuals
✍ Scribed by Claudia Istrate; Jorma Hinkula; Lennart Hammarström; Lennart Svensson
- Book ID
- 102386489
- Publisher
- John Wiley and Sons
- Year
- 2008
- Tongue
- English
- Weight
- 119 KB
- Volume
- 80
- Category
- Article
- ISSN
- 0146-6615
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✦ Synopsis
Abstract
While IgA is proposed to be essential to control rotavirus disease, no information is available how IgA deficient individuals modulate rotavirus disease and immune responses. In this study it was shown that patients (n = 62) with selective IgA deficiency (IgA‐D) (<0.05 g/L) resolve rotavirus disease and show higher total IgG and IgG1 subclass antibody titers to rotavirus than IgA proficient individuals (n = 62) (geometric mean titer, GMT) 18,101 vs. 4,000 (P < 0.005); 8,463 vs. 1691, (P < 0.005). It is concluded that IgA is not essential for resolving rotavirus disease in humans. J. Med. Virol. 80:531–535, 2008. © 2008 Wiley‐Liss, Inc.