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Individual variability in the translational regulation of ribosomal protein synthesis inXenopus laevis

โœ Scribed by Claudia Bagni; Paolo Mariottini; Luciano Terrenato; Francesco Amaldi

Publisher
Springer
Year
1992
Tongue
English
Weight
494 KB
Volume
234
Category
Article
ISSN
1617-4615

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โœฆ Synopsis

Ribosomal protein synthesis is regulated by controlling the fraction of mRNA associated with polysomes. It is known that this value changes in different developmental stages during Xenopus embryogenesis or, more generally, with changing cell growth conditions. We present here an analysis of the proportion of mRNA loaded on polysomes, carried out with probes for five different ribosomal proteins on several batches of Xenopus embryos obtained from different individuals. The results obtained indicate the existence of probe-dependent and individual differences, which reflect genetic variations in the cis- and trans-acting regulatory elements responsible for translational regulation. The fraction of ribosomal protein mRNA loaded onto polysomes can be used as an index of an individual's capacity for ribosome production.

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