Individual values of excretion of benzo[a]pyrene metabolites and susceptibility to its carcinogenic effect in rats
โ Scribed by Tyndyk, Margarita L.; Zabezhinski, Mark A.; Bykov, Vladimir J.; Dikun, Pavel P.; Dymochka, Larisa A.; Nepomnyaschaya, Olga B.; Yatsuk, Olga S.; Yermilov, Vladimir B.; Likhachev, Alexei J.
- Book ID
- 122378475
- Publisher
- Elsevier Science
- Year
- 1994
- Tongue
- English
- Weight
- 668 KB
- Volume
- 78
- Category
- Article
- ISSN
- 0304-3835
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๐ SIMILAR VOLUMES
3-hydroxy-benzo(a)pyrene (3-OH-B(a)P) and mutagenic activity in rat urine were determined after the oral administration of benzo(a)pyrene given in three repeated doses of 10, 20 and 50 pmol kg-'. The procedure for the determination of 3-OH-B(a)P consisted of enzymic hydrolysis, separation and HPLC-a
## Abstract The toxicokinetics of benzo(a)pyrene (BaP) and 3โhydroxybenzo(a)pyrene (3โOHBaP) were assessed in 36 male SpragueโDawley rats injected intravenously with 40 ยตmolโkg^1^ of BaP to explain the reported atypical urinary excretion profile of 3โOHBaP. Blood, liver, kidney, lung, adipose tissu