Individual specific DNA fingerprints from a hypervariable region probe: alpha-globin 3′HVR
✍ Scribed by Susan J. Fowler; Peter Gill; David J. Werrett; Douglas R. Higgs
- Book ID
- 104701843
- Publisher
- Springer
- Year
- 1988
- Tongue
- English
- Weight
- 905 KB
- Volume
- 79
- Category
- Article
- ISSN
- 0340-6717
No coin nor oath required. For personal study only.
✦ Synopsis
A probe detecting a hypervariable region (HVR) 3' to the alpha globin locus on chromosome 16 has been used to produce DNA fingerprints. Segregation analysis has revealed multiple, randomly dispersed DNA fragments inherited in a Mendelian fashion with minimal allelism and linkage. The fingerprints are highly polymorphic (probability of chance association between random individuals much less than 10(-14]. The probe is, therefore, a powerful discriminating tool: it is envisaged that this probe will have forensic applications, including paternity cases, and will be informative in linkage analysis.