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Indium trichloride catalyzed three component one-pot route to 1-hydroxymethyl-3-aminomethyl indoles

✍ Scribed by Chiranjit Acharya; Sumit Dey; Parasuraman Jaisankar


Book ID
116909821
Publisher
Elsevier Science
Year
2012
Tongue
French
Weight
431 KB
Volume
53
Category
Article
ISSN
0040-4039

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## Abstract An efficient route to 2β€²,3′‐dihydro‐2′‐thioxospiro[indole‐3,6′‐[1,3]thiazin]‐2(1__H__)‐one derivatives is described. It involves the reaction of isatine, 1‐phenyl‐2‐(1,1,1‐triphenyl‐__Ξ»__^5^‐phosphanylidene)ethan‐1‐one, and different amines in the presence of CS~2~ in dry MeOH at reflux