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Indium-Mediated Reaction of Trialkylsilyl Propargyl Bromide with Aldehydes: Highly Regioselective Synthesis of Allenic and Homopropargylic Alcohols

โœ Scribed by Lin, Man-Jing; Loh, Teck-Peng


Book ID
119966836
Publisher
American Chemical Society
Year
2003
Tongue
English
Weight
55 KB
Volume
125
Category
Article
ISSN
0002-7863

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Indium-mediated highly regioselective re
โœ Byung-Woo Yoo; Sung-Jae Lee; Kwang-Hyun Choi; Sam-Rok Keum; Jae-Jung Ko; Kyung-I ๐Ÿ“‚ Article ๐Ÿ“… 2001 ๐Ÿ› Elsevier Science ๐ŸŒ French โš– 52 KB

Indium-mediated reaction of acyl cyanides 1 with prop-2-ynyl bromides 2 in aqueous media occurs regioselectively to afford either allenic 3 or propargylic ketones 4 depending on the g-substituent of the prop-2-ynyl bromide under the mild conditions.