Indirect presynaptic modulation of striatal dopamine release by GABAB receptors in the rat substantia nigra
β Scribed by Norbert Balon; Badreddine Kriem; Michel Weiss; Jean-Claude Rostain
- Book ID
- 117472698
- Publisher
- Elsevier Science
- Year
- 2002
- Tongue
- English
- Weight
- 110 KB
- Volume
- 325
- Category
- Article
- ISSN
- 0304-3940
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The role of specific dopamine receptor subtypes in the regulation of GABA release in the substantia nigra was investigated using microdialysis in the awake rat. Both basal and potassium-stimulated changes in the extracellular concentrations of GABA were examined in response to the local perfusion of
Previous electrophysiological experiments have emphasized the importance of the firing pattern for the functioning of midbrain dopamine (DA) neurons. In this regard, excitatory amino acid receptors appear to constitute an important modulatory control mechanism. In the present study, extracellular re