Indirect Kinetic Catalytic Determination of Organic Compounds: Analysis for Bromazepam by the Stopped-Flow Technique
✍ Scribed by M. Carmona; M. Silva; D. Perezbendito
- Publisher
- Elsevier Science
- Year
- 1993
- Tongue
- English
- Weight
- 450 KB
- Volume
- 48
- Category
- Article
- ISSN
- 0026-265X
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✦ Synopsis
A new approach to the indirect kinetic catalytic determination of organic compounds is reported. It involves the selective organic-solvent extraction of the chelate formed between a suitable metal ion and the organic compounds concerned, which is followed by backextraction of the metal ion into aqueous phase and its subsequent determination by a kinetic catalytic stopped-flow method. The proposed methodology combines the high selectivity of the extraction process with the high sensitivity of catalytic reactions. It was illustrated with the determination of bromazepam over the range (1.5-18.75 \mu \mathrm{g} \mathrm{ml}^{-1}) and applied to the analysis of this drug in plasma with no interference from other benzodiazepines. (O) 1993 Academic Press, Inc.