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Indirect imaging of ethanol via magnetization transfer at high and low magnetic fields

✍ Scribed by Mohammad R. Estilaei; Gerald B. Matson; Dieter J. Meyerhoff

Publisher
John Wiley and Sons
Year
2003
Tongue
English
Weight
255 KB
Volume
49
Category
Article
ISSN
0740-3194

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✦ Synopsis

Abstract

Ethanol (EtOH) is believed to exert its neurochemical effects through interactions with brain cellular components, which causes a fraction of brain EtOH to have a lower molecular mobility. This facilitates magnetization transfer to other molecules similarly associated with macromolecules, such as water. It was hypothesized that this effect can be used in vivo to image EtOH indirectly via the much stronger brain tissue water resonance. EtOH‐containing bovine serum albumin samples were used to demonstrate magnetic coupling between EtOH and water at 7 T and 1.5 T. Spectroscopy and imaging experiments demonstrated that EtOH signal saturation yielded greater water signal reduction than inversion and that this reduction scaled with EtOH concentration in the BSA samples. In human brain at physiologically relevant brain EtOH concentrations, water signal reductions were measurable when saturating the EtOH resonance. Strengths and limitations of indirectly imaging brain EtOH are discussed. Magn Reson Med 49:755–759, 2003. © 2003 Wiley‐Liss, Inc.

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