## Abstract Methylglyoxal bis(guanylhydrazone), a cytostatic compound which apparently interferes with the metabolism and/or functions of the natural polyamines (spermidine and spermine), was effectively taken up by cultured human lymphocytic leukemia cells, rapidly resulting in the formation of a
✦ LIBER ✦
Indirect determination of methylglyoxal bis(guanylhydrazone) in leukocytes of leukemia patients
✍ Scribed by P. Seppänen; L. Alhonen-Hongisto; J. Jänne; A. Raina; T. Eloranta
- Book ID
- 115823860
- Publisher
- Elsevier Science
- Year
- 1982
- Tongue
- English
- Weight
- 452 KB
- Volume
- 123
- Category
- Article
- ISSN
- 0009-8981
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A high-pressure liquid chromatographic method was utilized to determine the concentration of the antileukemic agent methylgloxal bis(guanylhydrazone) (MGBG, NSC-32946) in tissue samples obtained at autopsy from patients who received MGBG. In a patient with cholangiocarcinoma who received one course