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Indicators of hypoxia in cerebrospinal fluid of hydrocephalic children with suspected shunt malfunction

✍ Scribed by M. Castro-Gago; S. Rodríguez-Segade; F. Camiña; A. Bollar; A. Rodríguez-Núñez

Publisher
Springer
Year
1993
Tongue
English
Weight
237 KB
Volume
9
Category
Article
ISSN
0256-7040

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✦ Synopsis

We used high performance liquid chromatography to determine the concentration of purine metabolites in the cerebrospinal fluid of three hydrocephalic children with a history of shunt malfunction. Hypoxanthine and xanthine levels were high in comparison with controls. We consider these purines to be valuable indicators of disturbance of neuronal metabolism following the sustained rise in intracranial pressure caused by shunt valve malfunction.

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