Sonic hedgehog (Shh) is a key signal protein in early embryological patterning of limb bud development. Its analog, Indian hedgehog (Ihh), primarily expressed during early cartilage development in prehypertrophic chondrocytes, regulates proliferation and suppresses terminal differentiation of postna
β¦ LIBER β¦
Indian hedgehog coordinates chondrocyte and osteoblast differentiation in the growth plate.
β Scribed by HM Kronenberg; Ung-il Chung
- Book ID
- 117807126
- Publisher
- Elsevier Science
- Year
- 2000
- Tongue
- English
- Weight
- 118 KB
- Volume
- 27
- Category
- Article
- ISSN
- 8756-3282
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## Abstract Perlecan is a heparan sulfate proteoglycan present in the growth plate and essential for endochondral ossification. We evaluated the synthesis and structure of perlecan in the different zones of the growth plate. The growth plates from fetal bovine ribs were isolated and sequentially sl