Independent clinical, histological and quantitative prognostic factors in transitional-cell bladder tumours, with special reference to mitotic frequency
✍ Scribed by P. K. Lipponen; M. J. Eskelinen; K. Jauhiainen; E. Harju; R. Terho; H. Haapasalo
- Publisher
- John Wiley and Sons
- Year
- 1992
- Tongue
- French
- Weight
- 728 KB
- Volume
- 51
- Category
- Article
- ISSN
- 0020-7136
No coin nor oath required. For personal study only.
✦ Synopsis
A cohort of 537 transitional-cell bladder cancers (TCC) was followed up for a mean of 9 years. Clinical stage, WHO grade, papillary status, 6 nuclear factors and volume-corrected mitotic index (M/V index) were related to progression and survival. Classic and quantitative prognostic factors were significantly interrelated (p < 0.001). In Ta-TI tumours M/V index predicted progression independently (p < 0.00 I) and in the entire cohort progression was related independently to the M/V index ( p = 0.OOOl) and to the WHO grade (p = 0.0022). In survival analysis, clinical stage (p < O.OOOl), M/V index (p < 0.000I), WHO grade (p < O.OOOl), papillary status (p < 0.OOOl) and nuclear factors (p < 0.000 I) were significant predictors. In papillary tumours, clinical stage (p < O.OOOl), M/V index (p < O.OOOl), WHO grade (p < 0.OOOl) and nuclear factors (p = 0.000 1-0.0 133) were related to survival. In a multivariate analysis T-category (p < O.OOl), WHO grade (p < O.OOl), M/V index (p = 0.002) and papillary status (p = 0.034) predicted survival independently in the entire cohort whereas in papillary tumours T-category (p < 0.001) and M/V index (p < 0.001) were independent predictors. If tumours with pelvic lymphnode metastases or distant metastases at diagnosis were excluded from the analysis, T-category ( p < O.OOl), M/V index (p < 0.001) and WHO grade ( p < 0.001) were independent predictors. In papillary tumours T-category (p < O.OOl), M/V index (p < 0.001) and WHO grade (p = 0.048) predicted sur-~