Independent activation of endogenous p21-activated protein kinase-3 (PAK3) and JNK by thrombin in CCL39 fibroblasts

Transcription activation of myostatin by

Transcription activation of myostatin by trichostatin A in differentiated C2C12 myocytes via ASK1-MKK3/4/6-JNK and p38 mitogen-activated protein kinase pathways

✍ Der-Sheng Han; Hsiang-Po Huang; Tyng-Guey Wang; Meng-Yu Hung; Jia-Yu Ke; Kuei-Ti 📂 Article 📅 2010 🏛 John Wiley and Sons 🌐 English ⚖ 433 KB

## Abstract Myostatin is a negative regulator of skeletal muscle mass. The pathways employed in modulating myostatin gene expression are scarcely known. We aimed to determine the signaling pathway of myostatin induction by a histone deacetylase (HDAC) inhibitor–trichostatin A (TSA) in differentiate