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Incremental Contribution to Protein Stability from a β Hairpin “Finger”: Limits on the Stability of Designed β Hairpin Peptides

✍ Scribed by Mark S. Searle; Geoffrey W. Platt; Roger Bofill; Stephen A. Simpson; Barbara Ciani


Publisher
John Wiley and Sons
Year
2004
Tongue
English
Weight
163 KB
Volume
43
Category
Article
ISSN
0044-8249

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β-Hairpin stabilization in a 28-residue
✍ R. A. G. D. Silva; Simon A. Sherman; Timothy A. Keiderling 📂 Article 📅 1999 🏛 Wiley (John Wiley & Sons) 🌐 English ⚖ 161 KB 👁 1 views

The beta-subunit of the human chorionic gonadotropin (hCG) hormone, which is believed to be related to certain types of cancer, contains three hairpin-like fragments. To investigate the role of beta-hairpin formation in the early stages of the hCGbeta folding, a 28-residue peptide with the sequence