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Increasing the efficacy of tumor cell vaccines by enhancing cross priming

✍ Scribed by Brian M. Andersen; John R. Ohlfest

Book ID
119211704
Publisher
Elsevier Science
Year
2012
Tongue
English
Weight
222 KB
Volume
325
Category
Article
ISSN
0304-3835

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## Abstract Though TGF‐β inhibition enhances antitumor immunity mediated by CD8^+^ T cells in several tumor models, it is not always sufficient for rejection of tumors. In this study, to maximize the antitumor effect of TGF‐β blockade, we tested the effect of anti‐TGF‐β combined with an irradiated