๐”– Bobbio Scriptorium
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Increasing the accumulation of daunorubicin in human leukemic cells by prolonging the infusion time

โœ Scribed by Christer Paul; Ulf Tidefelt; Jan Liliemark; Curt Peterson


Book ID
113239133
Publisher
Elsevier Science
Year
1989
Tongue
English
Weight
481 KB
Volume
13
Category
Article
ISSN
0145-2126

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## Multidrug -resistance (MDR) is characterized by the presence of a 170 kDa glycoprotein (P-glycoprotein) in the plasma membrane. P-glycoprotein is thought to act as an efflux pump, leading to reduced drug accumulation in MDR cells. This defect in drug accumulation can be overcome by membrane tra