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Increasing ceramides sensitizes genistein-induced melanoma cell apoptosis and growth inhibition

โœ Scribed by Chao Ji; Yan-li Yang; Li He; Bing Gu; Ji-ping Xia; Wei-ling Sun; Zhong-lan Su; Bin Chen; Zhi-gang Bi


Book ID
116303311
Publisher
Elsevier Science
Year
2012
Tongue
English
Weight
577 KB
Volume
421
Category
Article
ISSN
0006-291X

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โœ Shawn G. Payne; David N. Brindley; Larry J. Guilbert ๐Ÿ“‚ Article ๐Ÿ“… 1999 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 155 KB

The activation of sphingomyelinase and the subsequent generation of ceramide are emerging as important components of signaling pathways leading to apoptosis. The combination of tumor necrosis factor-alpha (TNF-alpha) and interferon-gamma (IFN-gamma) induces apoptosis of primary placental trophoblast