Increases levels of circulating intercellular adhesion molecule-1 in multiple sclerosis and human T-lymphotropic virus type I-associated myelopathy

✍ Scribed by Dr.; MD; PhD N. Tsukada; MD; PhD K. Miyagi; MD; PhD M. Matsuda; MD; PhD N. Yanagisawa

• Publisher: John Wiley and Sons
• Year: 1993
• Tongue: English
• Weight: 445 KB
• Volume: 33
• Category: Article
• ISSN: 0364-5134
• DOI: 10.1002/ana.410330614

✦ Synopsis

We evaluated the presence of soluble intercellular adhesion molecule-1 (SICAM-I) antigen in the sera of patients with multiple sclerosis and human T-lymphotropic virus type I (HTLV-I)-associated myelopathy (HAM) using an enzyme-linked immunosorbent assay. Patients with multiple sclerosis in the active phase had higher sICAM serum levels than did control subjects ( p < 0.01). In addition, a significantly increased serum level of sICAM-I was found in patients with HAM ( p < 0.001).

Furthermore, we found a positive correlation with HAM sICAM-1 and tumor necrosis factor-a levels in the sera of patients with multiple sclerosis in the active phase (Y = 0.88, p < 0.01) and in those with HAM (Y = 0.86, p < 0.01). These results suggest that serum SICAM-1 may be related to clinical activity in patients with multiple sclerosis and the detection of sICAM-1 could be useful as a marker of inflammatory disease.