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Increases in transforming growth factor-β mRNA in hippocampus during response to entorhinal cortex lesions in intact and adrenalectomized rats

✍ Scribed by Ph.D. N. R. Nichols; N. J. Laping; J. R. Day; C. E. Finch

Book ID: 102911951
Publisher: John Wiley and Sons
Year: 1991
Tongue: English
Weight: 643 KB
Volume: 28
Category: Article
ISSN: 0360-4012
DOI: 10.1002/jnr.490280114

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✦ Synopsis

Transforming growth factor-p mRNA was detected with a rat TGF-Pl coding sequence probe as a 2.5 kb band by RNA blot hybridization of total RNA from the adult male rat hippocampus. Following electrolytic lesions of the entorhinal cortex that cause hippocampal deafferentation and synaptic remodeling, TGF-P mRNA increases 5-fold in ipsilateral hippocampus when compared with intact controls. This increase was independent of prior adrenalectomy or corticosterone-replacement. These data demonstrate that TGF-P gene expression increases in response to hippocampal deafferentation.

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