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Increased transversions in a novel mutator colon cancer cell line

โœ Scribed by Eshleman, James R; Donover, P Scott; Littman, Susan J; Swinler, Sandra E; Li, Guo-Min; Lutterbaugh, James D; Willson, James KV; Modrich, Paul; Sedwick, W David; Markowitz, Sanford D

Book ID
110061182
Publisher
Nature Publishing Group
Year
1998
Tongue
English
Weight
315 KB
Volume
16
Category
Article
ISSN
0950-9232

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A candidate murine tumor-suppressor gene, Mom1, has been identified as the secretory phospholipase A2 (GDB nomenclature: PLA2G2A) gene. Evidence suggests that PLA2G2A functions as a tumor-suppressor because mice lacking PLA2G2A expression demonstrate increased colonic polyposis. The human homologue