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Increased transduction of human intestinal epithelial cells by adenoviral vectors in inflammatory bowel disease

✍ Scribed by Phyllissa Schmiedlin-Ren; Filippos Kesisoglou; John A Mapili; Sayed E Sabek; Jeffrey L Barnett; William D Chey; Blake Roessler; Ellen M Zimmermann


Book ID
110087184
Publisher
John Wiley and Sons
Year
2005
Tongue
English
Weight
620 KB
Volume
11
Category
Article
ISSN
1078-0998

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Background: Wnt signaling regulates intestinal epithelial stem cell function. Wnt ligands bind Frizzled (Fz) receptors and lowdensity lipoprotein-receptor-related protein (LRP) 5 and 6. Secreted Frizzled-related protein (SFRP) and Dickkopf families inhibit Wnt signaling. Our aim was to study express