Oxidative damage is increased in human l
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Christoph JΓΌngst; Bin Cheng; Ralph Gehrke; Volker Schmitz; Hans Dieter Nischalke
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Article
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2004
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John Wiley and Sons
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English
β 181 KB
Accumulation of genetic alterations in hepatocarcinogenesis is closely associated with chronic inflammatory liver disease. 8-oxo-2-deoxyguanosine (8-oxo-dG), the major promutagenic DNA adduct caused by reactive oxygen species (ROS), leads to G:C 3 T:A transversions. These lesions can be enzymaticall