Increased stability of templates for some enzymes of DNA synthesis in tumors: Deoxycytidylate deaminase, thymidine and thymidylate kinase
✍ Scribed by Jay S. Roth
- Book ID
- 118933144
- Publisher
- Elsevier Science
- Year
- 1964
- Tongue
- English
- Weight
- 200 KB
- Volume
- 3
- Category
- Article
- ISSN
- 0024-3205
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## Abstract Cytosol thymidine kinase (TK) and deoxycytidylate (dCMP) deaminase formation was investigated in synchronized cultures of K12 Chinese hamster cells which have a temperature‐sensitive lesion affecting the initiation of DNA synthesis. Enzyme formation was found to be cycloheximide‐sensiti
The inhibitors of DNA synthesis, 5-fluoro-2'-deoxyuridine and hydroxyurea, caused an inhibition of thymidine kinase, replicative DNA polymerase and CDP reductase activities in stimulated lymphocytes when they were exposed to the inhibitors during the early transformation period (0-17 hr). However, t