Increased shock-induced attack after repeated chlordiazepoxide administration in mice

Lack of inducible nitric oxide synthase

Lack of inducible nitric oxide synthase leads to increased hepatic apoptosis and decreased fibrosis in mice after chronic carbon tetrachloride administration

✍ Ghazaleh Aram; James J. Potter; Xiaopu Liu; Michael S. Torbenson; Esteban Mezey 📂 Article 📅 2008 🏛 John Wiley and Sons 🌐 English ⚖ 696 KB

The role of nitric oxide (NO) in liver injury and fibrosis is unclear. The purpose of this study was to determine whether inducible NO synthase deficiency (iNOS(-/-)) affects liver injury and fibrosis produced in mice by chronic carbon tetrachloride (CCl(4)) administration. Wild-type (WT) or iNOS(-/