Increased serum antibody levels against Cow's milk proteins in children with chronic liver disease
✍ Scribed by Aaron Lerner; Byung H. Park; Thomas M. Rossi; Emanual Lebenthal
- Publisher
- John Wiley and Sons
- Year
- 1985
- Tongue
- English
- Weight
- 439 KB
- Volume
- 5
- Category
- Article
- ISSN
- 0270-9139
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✦ Synopsis
We measured IgG, IgM and IgA antibodies to cow's milk proteins: a-casein, a-lactalbumin, bovine serum albumin, 8-lactoglobulin-a and &lactoglobulin-b in the sera of 29 pediatric patients with liver disease. IgG antibodies to bovine serum albumin, @-lactoglobulin-a and B-lactoglobulin-b and IgA antibodies to a-casein were elevated in most of the patients compared to age-matched controls. We postulate that, in patients with liver disease either increased intestinal uptake resulting in increased humoral response, or decreased hepatic clearance of food antigens intensifying a humoral response to these foreign antigens, may occur.