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Increased sensitivity to the locomotor depressant effect of a dopamine receptor antagonist during cocaine withdrawal in the rat

✍ Scribed by B. A. Baldo; Athina Markou; George F. Koob


Publisher
Springer
Year
1999
Tongue
English
Weight
133 KB
Volume
141
Category
Article
ISSN
0033-3158

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The ability of the mixed D1/D2 dopamine (DA) receptor antagonist cis-flupentixol to impair locomotor behavior in adult rats depleted of DA as weanlings was determined. Rats received lateral ventricular injections of 6-hydroxydopamine (100-200 micrograms/hemisphere) or its vehicle solution on postnat