Increased Sensitivity to N-Methyl-D-Aspartate Receptor-Mediated Excitotoxicity in a Mouse Model of Huntington's Disease
β Scribed by Melinda M Zeron; Oskar Hansson; Nansheng Chen; Cheryl L Wellington; Blair R Leavitt; Patrik Brundin; Michael R Hayden; Lynn A Raymond
- Book ID
- 117608117
- Publisher
- Elsevier Science
- Year
- 2002
- Tongue
- English
- Weight
- 377 KB
- Volume
- 33
- Category
- Article
- ISSN
- 0896-6273
No coin nor oath required. For personal study only.
π SIMILAR VOLUMES
We used two mouse models of Huntington's disease (HD) to examine changes in glutamate receptor sensitivity and striatal electrophysiology. One model, a transgenic, consisted of mice expressing exon 1 of the human HD gene and carrying 141-157 CAG repeat sequences (R6/2 line). The second model, a CAG
Huntington's disease (HD) is an autosomal dominant neurodegenerative disorder that affects primarily the striatum and cerebral cortex. A search for the factors that increase the vulnerability of striatal neurons will lead to a better understanding of the pathological cascades of this disease. A curr