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Increased sensitivity of the obese Zucker rat to DOCA-salt-induced hypertension

✍ Scribed by R.G Morrison; S.K Moore; E.I Mangiarua; G.L Wright; W.D McCumbee

Book ID
117600404
Publisher
Nature Publishing Group
Year
2001
Tongue
English
Weight
42 KB
Volume
14
Category
Article
ISSN
0895-7061

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## Abstract The pharmacokinetics and pharmacodynamics of bumetanide were investigated after intravenous (i.v.) administration, 10 mg kg^βˆ’1^, and oral administration, 20 mg kg^βˆ’1^, to spontaneously hypertensive rats (SHRs) and deoxycorticosterone acetate‐salt induced hypertensive rats (DOCA‐salt rat