Increased Sensitivity of Mitochondrial Respiration to Inhibition by Nitric Oxide in Cardiac Hypertrophy
β Scribed by Paul S. Brookes; Junxuan Zhang; Lijun Dai; Fen Zhou; Dale A. Parks; Victor M. Darley-Usmar; Peter G. Anderson
- Book ID
- 115633145
- Publisher
- Elsevier Science
- Year
- 2001
- Tongue
- English
- Weight
- 249 KB
- Volume
- 33
- Category
- Article
- ISSN
- 0022-2828
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## Abstract There is an increasing body of evidence demonstrating that inhibition of cytochrome c oxidase by nitric oxide (NO) may be one more step in a signaling cascade involved in the physiologic regulation of cell functions. For example, in both astrocytes and neurons the inhibition of mitochon
Nitric oxide (NO) modulates the fluidity of a variety of membranes. Thus, the aim of the present work was to study if the inhibitory effect of NO on mitochondrial respiration is associated with its effects on membrane fluidity. Liver mitochondria and an inner mitochondrial membrane fraction (IMMF) w