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Increased sensitivity of EBNA2-transformed rat fibroblasts to ionizing radiation

✍ Scribed by Misuzu Shimakage; Yoshiaki Miyata; Hirokazu Inoue; Masuo Yutsudo; Akira Hakura

Publisher
John Wiley and Sons
Year
1996
Tongue
French
Weight
461 KB
Volume
68
Category
Article
ISSN
0020-7136

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✦ Synopsis

To clarify whether expression of Epstein-Barr virus(EBV) nuclear antigen 2 (EBNA2) correlates with sensitivity to ionizing radiation, we tested EBNA2-transformed rat fibroblast clones for their radiosensitiviky to X-rays. These transformed clones reproducibly generated tumors in mice. X-irradiation suppressed the growth of the tumors, and irradiated mice survived longer than non-irradiated ones. In contrast, tumors formed by activated H-ras or E&E7 genes of human papillomavirus type I 6 (HPV16) were strongly resistant to the same dose of X-irradiation. In in vitro culture, these EBNA2-expressing clones also showed higher radiosensitivity than cell lines transformed by activated H-ras and E6E7 genes. The averaged Do of EBNA2expressing clones was 2.3 times lower than that of nonexpressing and control clones. These results suggest that

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