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Increased sensitivity for detection of carcinogen-induced DNA repair with the chain terminator dideoxythymidine

โœ Scribed by Gary J. Smith; Ronald K. Charlton; Joe W. Grisham; David G. Kaufman


Book ID
118312930
Publisher
Elsevier Science
Year
1978
Tongue
English
Weight
361 KB
Volume
83
Category
Article
ISSN
0006-291X

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A recent National Toxicology Program evaluation indicates that the rat hepatocyte/DNA repair assay has a high false-negative rate and that it is insensitive to some genotoxic hepatocarcinogens as well as other species and organ-specific carcinogens. In this study, we examined whether the sensitivity