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Increased seizure severity and seizure-related death in mice lacking HCN1 channels

✍ Scribed by Bina Santoro; Janet Y. Lee; Dario J. Englot; Sandra Gildersleeve; Rebecca A. Piskorowski; Steven A. Siegelbaum; Melodie R. Winawer; Hal Blumenfeld

Book ID
109111694
Publisher
Wiley (Blackwell Publishing)
Year
2010
Tongue
English
Weight
228 KB
Volume
51
Category
Article
ISSN
0013-9580

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## Abstract The glial water channel aquaporin‐4 (AQP4) has been hypothesized to modulate water and potassium fluxes associated with neuronal activity. In this study, we examined the seizure phenotype of AQP4 βˆ’/βˆ’ mice using in vivo electrical stimulation and electroencephalographic (EEG) recording.