Increased risk of cancer in the descendants of syrian hamsters exposed prenatally to diethylnitrosamine (DEN)
✍ Scribed by U. Mohr; M. Emura; K. Kamino; J. Steinmann; M. Kohler; G. Morawietz; C. Dasenbrock; L. Tomatis
- Publisher
- John Wiley and Sons
- Year
- 1995
- Tongue
- French
- Weight
- 694 KB
- Volume
- 63
- Category
- Article
- ISSN
- 0020-7136
No coin nor oath required. For personal study only.
✦ Synopsis
Transmission of site-specific tumorigenicity (papillomas in larynx and trachea) of diethylnitrosamine (DEN) to the 2 subsequent generations (F, and F2) was studied using an outbred strain (Han:AURA) of pregnant Syrian golden hamsters (P generation), which were treated i.p. with 10 mg/kg b.w. of DEN on day 12. 13 or 14 of gestation. Laryngotracheal papillomas were induced by DEN in the P and F, generations only, while these tumours did not occur in the F2 generation. Spontaneously occurring turnours, including uterine adenocarcinomas, lymphomas, and laryngotracheal neuro-endocrine cell tumours, were observed at higher incidences among the F1 animals derived from the P generation hamsters treated with DEN only on day I 3 or 14 of gestation. In the same animals, the ratio of malignant to benign tumours was considerably higher than in controls. In addition, the F2 hamsters derived from the DENtreated P generation showed more frequent multiple organ involvement in tumorigenesis than the F2 controls. Several uncommon malignant tumours were detected in the F2 offspring, possibly the result of damage caused to germ cells by the prenatal exposure of F, Syrian hamsters to DEN.