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Increased risk of Alzheimer's disease in Type II diabetes: insulin resistance of the brain or insulin-induced amyloid pathology?

✍ Scribed by Biessels, G.J.; Kappelle, L.J.


Book ID
121812803
Publisher
Portland Press
Year
2005
Tongue
English
Weight
101 KB
Volume
33
Category
Article
ISSN
0300-5127

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## Abstract We have evaluated the effect of peripheral insulin deficiency on brain insulin pathway activity in a mouse model of type 1 diabetes, the parallels with Alzheimer's disease (AD), and the effect of treatment with insulin. Nine weeks of insulin‐deficient diabetes significantly impaired the