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Increased reproductive success of MHC class

✍ Scribed by Ulrike Sauermann; Peter Nürnberg; Fred Bercovitch; John Berard; Andrea Trefilov; Anja Widdig; Matt Kessler; Jörg Schmidtke; Michael Krawczak


Book ID
106137362
Publisher
Springer
Year
2001
Tongue
English
Weight
43 KB
Volume
108
Category
Article
ISSN
0340-6717

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The Ts65Dn mouse is trisomic for orthologs of about half the genes on Hsa21. A number of phenotypes in these trisomic mice parallel those in humans with trisomy 21 (Down syndrome), including cognitive deficits due to hippocampal malfunction that are sufficiently similar to human that “therapies” dev