Sensitivity to DNA cross-linking chemoth
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Silvia Fiumicino; Simone Martinelli; Claudia Colussi; Gabriele Aquilina; Carlo L
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Article
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2000
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John Wiley and Sons
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French
⚖ 150 KB
👁 1 views
Together with tolerance to killing induced by methylating agents, loss of mismatch repair (MMR) has previously been found to be associated with hypersensitivity to the DNAcross-linking agent 1-(2-chloroethyl)-3-cyclohexyl-nitrosourea(CCNU) in several human tumor cell lines (Aquilina et al., 1998). H