## Abstract Gentamicin‐loaded acrylic beads are loosely placed in infected bone cavities, whereas gentamicin‐loaded acrylic bone cement is used as a mechanical filler in bone to anchor prosthetic components. Both drug delivery systems are used to decrease infection rates by gentamicin release. The
Increased release of gentamicin from acrylic bone cements under influence of low-frequency ultrasound
✍ Scribed by Johannes G.E. Hendriks; Geert T. Ensing; Jim R. van Horn; Jaap Lubbers; Henny C. van der Mei; Henk J. Busscher
- Book ID
- 114162565
- Publisher
- Elsevier Science
- Year
- 2003
- Tongue
- English
- Weight
- 140 KB
- Volume
- 92
- Category
- Article
- ISSN
- 0168-3659
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## Abstract Gentamicin is added to polymethylmethacrylate bone cements in orthopedics as a measure against infection in total joint arthroplasties. Numerous studies have been published on gentamicin release from bone cements, but none have been able to estimate the local concentrations in the prost
The purpose of this study was to characterize a poly(methyl methacrylate) bone cement that was loaded with the antibiotic gentamicin sulphate (GS) and lactose, which served to modulate the release of GS from cement specimens. The release of GS when the cement specimens were immersed in phosphatebuff