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Increased ratio between deoxycytidine kinase and thymidine kinase 2 in CLL lymphocytes compared to normal lymphocytes

โœ Scribed by Svend Erik Nielsen; Birgitte Munch-Petersen; Johannes Mejer


Book ID
113239857
Publisher
Elsevier Science
Year
1995
Tongue
English
Weight
424 KB
Volume
19
Category
Article
ISSN
0145-2126

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The inhibitors of DNA synthesis, 5-fluoro-2'-deoxyuridine and hydroxyurea, caused an inhibition of thymidine kinase, replicative DNA polymerase and CDP reductase activities in stimulated lymphocytes when they were exposed to the inhibitors during the early transformation period (0-17 hr). However, t