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Increased prostaglandin E2 concentrations and cyclooxygenase-2 expression in asthmatic subjects with sputum eosinophilia

✍ Scribed by Profita, M


Book ID
119491051
Publisher
Elsevier Science
Year
2003
Tongue
English
Weight
546 KB
Volume
112
Category
Article
ISSN
1097-6825

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Retinoic acid enhances prostaglandin E2
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Retinoic acid (RA) is a well-known antiinflammatory agent. In this study, we show that RA has a dual effect on cyclooxygenase-2 (COX-2) expression in inflammatory activated microglia, the resident brain macrophages. After treatment of microglia with LPS or thrombin, COX-2 expression was induced in t