𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Increased production of immune activation marker neopterin by colony-stimulating factors in gynecological cancer patients

✍ Scribed by Christian Marth; Günther Weiss; Astrid Koza; Gilbert Reibnegger; Günter Daxenbichler; Alain G. Zeimet; Dietmar Fuchs; Helmut Wachter; Otto Dapunt

Book ID
102277231
Publisher
John Wiley and Sons
Year
1994
Tongue
French
Weight
436 KB
Volume
58
Category
Article
ISSN
0020-7136

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✦ Synopsis

Granulocyte colony-stimulating factor (G-CSF) and granulocyte-macrophage colony-stimulating factor (GM-CSF) have recently been introduced in the treatment of chemotherapyinduced neutropenia. Effects of these CSFs on the cellular immune system were evaluated in 38 neutropenic gynecological cancer patients during chemotherapy. In addition to restoring the leukocyte count, GM-CSF-to a greater extent than G-CSF-also induced neopterin, a sensitive marker of macrophages activated by interferons. This effect was confirmed in vitro by investigating the effects of these CSFs on interferon-ymediated pathways in THP-I human myelomonocytic cells. The results suggest activation of immune effector cells by GM-CSF.

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