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Increased prevalence of varicella zoster virus DNA in cerebrospinal fluid from patients with multiple sclerosis

✍ Scribed by Roberta Mancuso; Serena Delbue; Elisa Borghi; Elisabetta Pagani; Maria Gaetana Calvo; Domenico Caputo; Enrico Granieri; Pasquale Ferrante


Publisher
John Wiley and Sons
Year
2006
Tongue
English
Weight
115 KB
Volume
79
Category
Article
ISSN
0146-6615

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Increased prevalence of varicella zoster
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## Abstract In order to investigate the possible involvement of viruses in Multiple Sclerosis (MS), the study evaluated the presence of viral genomic sequences in cerebrospinal fluid (CSF), as markers of viral replication within the central nervous system (CNS). A total of 85 CSF samples were colle

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Cerebrospinal fluid (CSF) samples from 46 patients with encephalitis were studied f o r t h e presence of herpes simplex virus (HSV) types 1 and 2 and/or varicella zoster virus (VZV)-specific DNA sequences by the polymerase chain reaction (PCR) assay. Patients were studied because of detection of in

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## Abstract The role of viruses in the pathogenesis of multiple sclerosis (MS) is a subject of heated debate. The presence of six different neurotropic viruses was sought, including JC virus (JCV), varicella zoster virus (VZV), human herpesvirus 6 (HHV‐6), and Epstein‐Barr virus (EBV), in cerebrosp

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On the basis of alterations in varicella-zoster virus (VZV) antibody titers, it appears that Bell's palsy in some patients could be associated with VZV reactivation, that is, zoster sine herpete. To obtain stronger evidence of this association, polymerase chain reaction (PCR) was used to detect VZV