Condyloma acuminata from 12 women were examined for the presence of human papillomavirus DNA. Six of the women had HPV 6a, two had HPV 11a, one had a new HPV 6 subtype, and one a new HPV 11 subtype. The new HPV 6 subtype could be distinguished from other HPV 6 subtypes on the basis of Pst I fragment
Increased prevalence of human papillomaviruses in the lower genital tract of pregnant women
β Scribed by Achim Schneider; Marlies Hotz; Lutz Gissmann
- Publisher
- John Wiley and Sons
- Year
- 1987
- Tongue
- French
- Weight
- 563 KB
- Volume
- 40
- Category
- Article
- ISSN
- 0020-7136
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β¦ Synopsis
In order to evaluate the influence of pregnancy on the presence of human papillomavirus (HPV) in the lower female genital tract, cervical smears of 92 pregnant and 96 non-pregnant women, matched by age, were examined for the presence of HPV-DNA by means of Southern blot hybridization. All patients had negative PAP smears. Twenty-six (28%) of the pregnant women and I2 (12.5%) of the non-pregnant women were positive for HPV. HPV 16 accounted for 42Yo of all positive pregnant cases and only 25% of the positive nonpregnant cases. Smears of pregnant patients contained more than 10 pg viral D N A in 45% of the cases against 20% in the non-pregnant group. HPV 16 showed the most active replication in both groups. This study demonstrates an increased prevalence of HPV (preferentially of HPV 16) and a higher replication rate of viral DNA during pregnancy.
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