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Increased poly-(R)-3-hydroxybutyrate concentrations in streptozotocin (STZ) diabetic rats

✍ Scribed by R.N. Reusch; E.M. Bryant; D.N. Henry

Publisher
Springer
Year
2003
Tongue
English
Weight
74 KB
Volume
40
Category
Article
ISSN
0940-5429

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Effect of a new aldose reductase inhibitor, (E)-3-carboxymethyl-5-[(2E)-methyl-3-phenylpropenylidene]rhodanine (ONO-2235) on peripheral nerve disorders in streptozotocin-diabetic rats
✍ R. Kikkawa; I. Hatanaka; H. Yasuda; N. Kobayashi; Y. Shigeta; H. Terashima; T. M πŸ“‚ Article πŸ“… 1983 πŸ› Springer 🌐 English βš– 270 KB

A new aldose reductase inhibitor, (E)-3-carboxymethyl-5-[(2E-methyl-3-phenylpropenylidene]rhodanine (ONO-2235) was administered orally to streptozotocin-diabetic rats (60 mg/kg IV) for 14 days and its effect on motor nerve conduction velocity studied. The compound significantly improved motor nerve