Increased plasma levels of tissue factor pathway inhibitor-activated factor X complex in patients with disseminated intravascular coagulation

✍ Scribed by Yoshinaga Okugawa; Hideo Wada; Tomohiro Noda; Miho Sakakura; Takahiro Nakasaki; Rika Watanabe; Hiroshi Deguchi; Esteban C. Gabazza; Yoshitaka Mori; Masakatsu Nishikawa; Katsumi Deguchi; Tsutomu Nobori; Hiroshi Shiku

• Publisher: John Wiley and Sons
• Year: 2000
• Tongue: English
• Weight: 58 KB
• Volume: 65
• Category: Article
• ISSN: 0361-8609
• DOI: 10.1002/1096-8652(200011)65:3<210::aid-ajh6>3.0.co;2-p

✦ Synopsis

Plasma levels of tissue factor pathway inhibitor (TFPI)-activated factor Xa (FXa) complex were measured in patients with disseminated intravascular coagulation (DIC), pre-DIC, and DIC. Plasma levels of plasmin-plasmin inhibitor complex (PPIC), D-dimer, and soluble fibrin monomer (SFM) were significantly higher in patients with DIC than in those with pre-DIC or non-DIC; the levels of these hemostatic markers were significantly higher in patients with pre-DIC than in those with non-DIC. Plasma levels of thrombin-antithrombin complex (TAT) were significantly higher in patients with DIC or pre-DIC than in those with non-DIC. Plasma levels of tissue factor (TF), total TFPI, free TFPI, and TFPI-Xa complex were significantly higher in patients with DIC than in those with non-DIC. Plasma levels of TFPI-Xa complex were significantly increased in patients with pre-DIC as compared to those with non-DIC; however, plasma free TFPI levels were significantly decreased in patients with pre-DIC as compared to those with non-DIC. These findings suggest that free TFPI might be consumed in the pre-DIC state, thereby confirming the activation of the extrinsic pathway. Plasma levels of TFPI-Xa complex were significantly correlated with TF, free TFPI, and total TFPI. Increased plasma TFPI-Xa complex levels might be useful for the diagnosis of DIC or pre-DIC, particularly that occurring by activation of the extrinsic pathway of blood coagulation.